Network-driven anomalous transport is a fundamental component of

Index

Abstract

This paper analyzes high-resolution simulations of intracortical blood flow and transport to understand the macroscopic transport properties in the brain microcirculation. It finds that network-driven anomalous transport leads to critical regions of hypoxia or high amyloid-β concentration, relevant to Alzheimer's Disease. A Continuous-Time Random Walk (CTRW) theory is developed to capture these dynamics, predicting that critical regions appear earlier than expected under mild hypoperfusion. The findings provide a framework for understanding microvascular dysfunction in brain diseases.

Publisher

Nature Communications

Published On

Dec 15, 2021

Authors

Florian Goirand, Tanguy Le Borgne, Sylvie Lorthois

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