This paper analyzes high-resolution simulations of intracortical blood flow and transport to understand the macroscopic transport properties in the brain microcirculation. It finds that network-driven anomalous transport leads to critical regions of hypoxia or high amyloid-β concentration, relevant to Alzheimer's Disease. A Continuous-Time Random Walk (CTRW) theory is developed to capture these dynamics, predicting that critical regions appear earlier than expected under mild hypoperfusion. The findings provide a framework for understanding microvascular dysfunction in brain diseases.
Publisher
Nature Communications
Published On
Dec 15, 2021
Authors
Florian Goirand, Tanguy Le Borgne, Sylvie Lorthois
Tags
intracortical blood flow
brain microcirculation
anomalous transport
hypoxia
amyloid-β concentration
Continuous-Time Random Walk
microvascular dysfunction
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