Medicine and Health

Network-driven anomalous transport is a fundamental component of brain microvascular dysfunction

F. Goirand, T. L. Borgne, et al.

This groundbreaking research by Florian Goirand, Tanguy Le Borgne, and Sylvie Lorthois delves into the intricate dynamics of blood flow and transport in the brain, revealing how network-driven anomalous transport may lead to critical hypoxic conditions linked to Alzheimer's Disease. Their Continuous-Time Random Walk theory predicts critical regions emerging sooner than anticipated, shedding light on microvascular dysfunction in brain diseases.

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Abstract

This paper analyzes high-resolution simulations of intracortical blood flow and transport to understand the macroscopic transport properties in the brain microcirculation. It finds that network-driven anomalous transport leads to critical regions of hypoxia or high amyloid-β concentration, relevant to Alzheimer's Disease. A Continuous-Time Random Walk (CTRW) theory is developed to capture these dynamics, predicting that critical regions appear earlier than expected under mild hypoperfusion. The findings provide a framework for understanding microvascular dysfunction in brain diseases.

Publisher

Nature Communications

Published On

Dec 15, 2021

Authors

Florian Goirand, Tanguy Le Borgne, Sylvie Lorthois

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