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Metabolic Rewiring in Melanoma: A Lipid Droplet Dependency Linked to Pigmented Melanocytic State

Medicine and Health

Metabolic Rewiring in Melanoma: A Lipid Droplet Dependency Linked to Pigmented Melanocytic State

D. Lumaquin, E. Martinez, et al.

This groundbreaking study conducted by D. Lumaquin and colleagues at Memorial Sloan Kettering Cancer Center explores the metabolic dependency of pigmented melanoma, revealing that fatty acids from lipid droplets are critical for oxidative metabolism. Inhibiting lipid droplet formation shows promise as a therapeutic target to combat melanoma progression.... show more
Abstract
Publisher
Nature Communications
Published On
Jul 26, 2023
Authors
D. Lumaquin, E. Martinez, Y. Ma, S. Singh, E. Jimenez, C. Lee, T. Ho, A. Baggiolini, L. Sollelis, R.M. White
Tags
pigmented melanoma
metabolic dependency
oxidative metabolism
lipid droplets
therapeutic target
zebrafish
cell cycle

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