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Long-term efficacy of BCG vaccination in goat herds with a high prevalence of tuberculosis

Veterinary Science

Long-term efficacy of BCG vaccination in goat herds with a high prevalence of tuberculosis

C. Arrieta-villegas, A. Allepuz, et al.

This groundbreaking three-year trial evaluated the effectiveness of BCG vaccination across five goat herds facing high tuberculosis (TB) prevalence. Conducted by a team of dedicated researchers, it revealed significant TB incidence reductions in vaccinated goats, with systematic vaccination combined with the removal of positive unvaccinated animals showing great promise in curbing the disease's spread.

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Playback language: English
Abstract
This three-year trial assessed the efficacy of BCG vaccination in five goat herds with high tuberculosis (TB) prevalence. Animals negative on initial TB tests were vaccinated, as were all replacement kids. Interferon-gamma release assays (IGRAs) were conducted at months 6, 12, 24, and 36. Four of five farms showed prevalence reductions (93.5%, 28.5%, 23.2%, and 14.3%), with an overall 50% incidence reduction in vaccinated goats. However, adult vaccinated goats had higher incidences than kids. Unvaccinated positive animals and adult vaccinated goats increased infection risk in vaccinated animals. Systematic BCG vaccination combined with removal of positive unvaccinated animals may reduce TB prevalence.
Publisher
Scientific Reports
Published On
Nov 23, 2020
Authors
Claudia Arrieta-Villegas, Alberto Allepuz, Miriam Grasa, Maite Martín, Zoraida Cervera, Irene Mercader, Sergio López-Soria, Mariano Domingo, Bernat Pérez de Val
Tags
BCG vaccination
tuberculosis
goat herds
incidence reduction
infectious disease management

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