Medicine and Health

Implementation of pooled saliva tests for universal screening of cCMV infection

L. Merav, N. O. Shlomai, et al.

Discover a groundbreaking study by Lior Merav and colleagues that demonstrates the effectiveness of pooled saliva PCR screening for congenital cytomegalovirus (cCMV) in infants. Their innovative approach screened 15,805 infants, revealing promising results while saving resources. Join us to learn about the future of neurodevelopmental disability prevention through universal cCMV screening!

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Playback language: English

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Abstract

Congenital cytomegalovirus (cCMV) is a common intrauterine infection causing neurodevelopmental disabilities. This study assessed the implementation of pooled saliva polymerase chain reaction (PCR) tests for universal cCMV screening in two Jerusalem hospitals. Over 13 months, 15,805 infants (93.6% of all live births) were screened using a pooled approach (six infants per test), saving 83% of tests with minimal sensitivity loss. cCMV was detected in 54 infants (3.4 per 1,000); 55.6% were asymptomatic at birth. The study demonstrates the feasibility and benefits of pooled saliva testing for universal cCMV screening.

Publisher

Nature Medicine

Published On

Apr 01, 2024

Authors

Lior Merav, Noa Ofek Shlomai, Esther Oiknine-Djian, Orit Caplan, Ayala Livneh, Tal Sido, Amir Peri, Aviad Shtoyer, Eden Amir, Kerem Ben Meir, Yutti Daitch, Mila Rivkin, Esther Kripper, Irit Fogel, Hadar Horowitz, Sraya Greenberger, Mevaseret Cohen, Miriam Geal-Dor, Oren Gordon, Diana Averbuch, Zivanit Ergaz-Shaltiel, Smadar Eventov Friedman, Dana G. Wolf, Moran Yassour

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