Medicine and Health

Exosome based analysis for Space Associated Neuro-Ocular Syndrome and health risks in space exploration

S. K. Chakrabortty, Y. L. Khodor, et al.

This exciting research developed a cutting-edge exosome-based platform for profiling biological processes from body fluids, with significant implications for diagnosing Space Associated Neuro-Ocular Syndrome and monitoring intracranial pressure patients. Conducted by Sudipto K. Chakrabortty and colleagues, this study paves the way for innovative diagnostic methodologies.

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Abstract

This research developed a novel exosome-based platform for profiling biological processes from various body fluids. The platform is applicable for diagnosing and studying Space Associated Neuro-Ocular Syndrome (SANS) and monitoring patients with intracranial pressure issues. The study demonstrated that exosomes from different biofluids contain specific RNA transcripts; ISS urine collection hardware is compatible with the technology; and cDNA libraries from exosomal RNA can be stored dry at room temperature for longitudinal molecular cataloging.

Publisher

npj Microgravity

Published On

Sep 14, 2022

Authors

Sudipto K. Chakrabortty, Yevgenia L. Khodor, Robert R. Kitchen, Dulaney L. Miller, Kailey M. Babcock, Kyle S. Manning, Steven P. Lang, Vasisht Tadigotla, Wei Yu, Eric Bershad, Johan Skog, Susana Zanello

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