This research developed a novel exosome-based platform for profiling biological processes from various body fluids. The platform is applicable for diagnosing and studying Space Associated Neuro-Ocular Syndrome (SANS) and monitoring patients with intracranial pressure issues. The study demonstrated that exosomes from different biofluids contain specific RNA transcripts; ISS urine collection hardware is compatible with the technology; and cDNA libraries from exosomal RNA can be stored dry at room temperature for longitudinal molecular cataloging.
Publisher
npj Microgravity
Published On
Sep 14, 2022
Authors
Sudipto K. Chakrabortty, Yevgenia L. Khodor, Robert R. Kitchen, Dulaney L. Miller, Kailey M. Babcock, Kyle S. Manning, Steven P. Lang, Vasisht Tadigotla, Wei Yu, Eric Bershad, Johan Skog, Susana Zanello
Tags
exosome-based platform
biological processes
Space Associated Neuro-Ocular Syndrome
intracranial pressure
RNA transcripts
molecular cataloging
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