Biology

Early life experiences selectively mature learning and memory abilities

B. Bessières, A. Traglia, et al.

This exciting research by Benjamin Bessières, Alessio Traglia, Todd M. Mowery, Xinying Zhang, and Cristina M. Alberini delves into how infant rats and mice develop their learning and memory skills. Discover the fascinating biological changes in their hippocampus that enhance memory and learning processes, including the critical role of AMPA receptors.

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Abstract

This study investigates the maturation of learning and memory abilities in infant rats and mice. Episodic learning in infants leads to unique biological changes in the hippocampus, including persistent neuronal activation, BDNF-dependent increases in synapse markers, and AMPA receptor maturation. Inhibition of PSD-95 induction impairs both AMPA receptor maturation and infantile memory. Subsequent learning experiences or chemogenetic activation mature memory competence, but this maturation is selective for the type of experience encountered.

Publisher

Nature Communications

Published On

Jan 31, 2020

Authors

Benjamin Bessières, Alessio Traglia, Todd M. Mowery, Xinying Zhang, Cristina M. Alberini

DOI

https://doi.org/10.1038/s41467-020-14461-3

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