Psychology

Dynamic and selective engrams emerge with memory consolidation

D. F. Tomé, Y. Zhang, et al.

Discover how memory engrams evolve from unselective to selective through computational and experimental methods! This groundbreaking research by Douglas Feitosa Tomé and colleagues reveals the vital role of inhibitory synaptic plasticity in the dynamic landscape of memory formation and recall. Don't miss out on these insights into the complexities of memory consolidation!

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Abstract

This study used computational and experimental approaches to investigate how the neural composition and selectivity of memory engrams change during memory consolidation. A spiking neural network model predicted that memories transition from unselective to selective as neurons drop out of and into engrams; inhibitory activity during recall is crucial for memory selectivity; and inhibitory synaptic plasticity during consolidation is critical for selective engrams. Contextual fear conditioning experiments in mice supported these predictions, revealing dynamic memory engrams where changes in engram composition, mediated by inhibitory plasticity, are essential for memory selectivity.

Publisher

Nature Neuroscience

Published On

Mar 01, 2024

Authors

Douglas Feitosa Tomé, Ying Zhang, Tomomi Aida, Olivia Mosto, Yifeng Lu, Mandy Chen, Sadra Sadeh, Dheeraj S. Roy, Claudia Clopath

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