Psychology

Direct stimulation of anterior insula and ventromedial prefrontal cortex disrupts economic choices

R. Cecchi, A. Collomb-clerc, et al.

This groundbreaking research conducted by Romane Cecchi and colleagues reveals how specific neural stimulation in the brain affects our economic decision-making and confidence. By manipulating the ventral and dorsal regions of the anterior insula and ventromedial prefrontal cortex, they uncover vital insights into risk-taking behavior, demonstrating how our brains influence choices and self-assurance.

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Abstract

This study investigates the causal relationship between neural activity in the ventromedial prefrontal cortex (vmPFC) and anterior insula (aINS) and economic choices and confidence. Using intracranial electrical stimulation (IES) in epilepsy patients performing an economic choice task, the researchers found that stimulation of ventral aINS reduced risk-taking by increasing loss sensitivity, while dorsal aINS and ventral vmPFC stimulation increased risk-taking by reducing loss sensitivity. aINS stimulation consistently decreased confidence. These findings suggest functionally distinct subregions within the vmPFC and aINS causally involved in decision-making and confidence.

Publisher

Nature Communications

Published On

Aug 29, 2024

Authors

Romane Cecchi, Antoine Collomb-Clerc, Inès Rachidi, Lorella Minotti, Philippe Kahane, Mathias Pessiglione, Julien Bastin

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