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Differential survival of potentially pathogenic, septicemia- and meningitis-causing *E. coli* across the wastewater treatment train

Medicine and Health

Differential survival of potentially pathogenic, septicemia- and meningitis-causing *E. coli* across the wastewater treatment train

D. Yu, K. Ryu, et al.

This study by Daniel Yu, Kanghee Ryu, Simon J. G. Otto, Paul Stothard, Graham Banting, Norma Ruecker, Norman F. Neumann, and Shuai Zhi reveals alarming insights into the survival of pathogenic *E. coli* strains throughout wastewater treatment, highlighting their potential risks in transmitted wastewater effluents.

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Playback language: English
Abstract
This study investigated the survival of extraintestinal pathogenic *E. coli* (ExPEC) strains, including those causing septicemia and meningitis, throughout wastewater treatment. Analysis of isolates from chlorinated sewage and treated wastewater revealed a significant presence of presumptive ExPEC, clustering within pandemic lineages like ST131, ST95, and ST73. A substantial portion (37 isolates) showed high genomic similarity to clinical bloodborne (*BBEC*) and neonatal meningitic (*NMEC*) strains, suggesting similar pathogenic potential. Shared accessory genes with naturalized wastewater strains imply a common mechanism for water treatment survival. The study concludes that these potentially pathogenic *E. coli* strains survive wastewater treatment and pose a potential risk of transmission via wastewater effluents.
Publisher
npj Clean Water
Published On
Jul 20, 2022
Authors
Daniel Yu, Kanghee Ryu, Simon J. G. Otto, Paul Stothard, Graham Banting, Norma Ruecker, Norman F. Neumann, Shuai Zhi
Tags
extraintestinal pathogenic E. coli
wastewater treatment
septicemia
meningitis
pathogenic potential
water treatment survival
pandemic lineages
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