Developmental Exposure to Traffic-Related Air Pollution and | ResearchBunny

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Abstract

This study investigated the effects of developmental exposure to traffic-related air pollution (TRAP) on neuropathological outcomes in rats. Male and female Sprague-Dawley rats were exposed to TRAP or filtered air (FA) from gestational day 14 through postnatal day 47-51. Neuropathological assessments included MRI, immunohistochemistry, TUNEL staining, qPCR, and cytokine analysis. The study found TRAP exposure modulated the neuroinflammatory response, altered astrocyte reactivity, impacted cytokine levels, and affected hippocampal neurogenesis.

Publisher

Translational Psychiatry

Published On

Jun 17, 2020

Authors

Patten

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