Biology

Deep Brain Stimulation for Alzheimer's Disease: A Systematic Review and Meta-Analysis

A. Lavano, L. Furlanetti, et al.

Explore the impact of deep brain stimulation on cognitive function in Alzheimer's disease patients, as revealed by researchers Angelo Lavano, Luciano Furlanetti, Domenico La Torre, and Myles McLaughlin. Dive into the findings of a comprehensive systematic review and meta-analysis that sheds light on the current understanding and future directions for AD treatment.

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Playback language: English

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Abstract

Alzheimer's disease (AD) is a neurodegenerative disease affecting millions worldwide. This systematic review and meta-analysis assessed the effectiveness of deep brain stimulation (DBS) in improving cognitive function in AD patients. The analysis included six comparisons from five studies involving 66 participants. Results showed no significant overall effect of DBS on cognitive function. Subgroup analyses targeting the fornix and nucleus basalis of Meynert (NBM) also revealed non-significant effects. While some individual studies showed promising results, the overall conclusion highlights the need for larger, randomized controlled trials with standardized stimulation parameters to determine the efficacy of DBS as a treatment for AD.

Publisher

Frontiers in Neuroscience

Published On

Apr 01, 2022

Authors

Angelo Lavano, Luciano Furlanetti, Domenico La Torre, Myles Mc Laughlin

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