Medicine and Health

CSF proteome profiling reveals biomarkers to discriminate dementia with Lewy bodies from Alzheimer's disease

M. D. Campo, L. Vermunt, et al.

This study identifies specific cerebrospinal fluid protein changes unique to dementia with Lewy bodies (DLB), revealing over 50 dysregulated proteins, with Dopa decarboxylase (DDC) emerging as a key biomarker. Conducted by a team of experts including Marta del Campo and Alberto Lleó, it presents a practical 7-CSF biomarker panel to enhance the discrimination between DLB and Alzheimer's disease.

00:00

Playback language: English

Index

Abstract

Diagnosis of dementia with Lewy bodies (DLB) is challenging and specific biofluid biomarkers are highly needed. This study used proximity extension-based assays to measure 665 proteins in cerebrospinal fluid (CSF) from patients with DLB, Alzheimer's disease (AD), and controls. Over 50 CSF proteins were dysregulated in DLB, many related to myelination. Dopa decarboxylase (DDC) was the strongest dysregulated protein, effectively discriminating DLB from controls and AD. A 7-CSF biomarker panel further improved DLB/AD discrimination. A custom multiplex panel was validated in independent cohorts, including an autopsy-confirmed cohort. This study identifies DLB-specific protein changes and provides a practical biomarker panel for accurate DLB identification.

Publisher

Nature Communications

Published On

Sep 13, 2023

Authors

Marta del Campo, Lisa Vermunt, Carel F. W. Peeters, Anne Sieben, Yanaika S. Hok-A-Hin, Alberto Lleó, Daniel Alcolea, Mirrelijn van Nee, Sebastiaan Engelborghs, Juliette L. van Alphen, Sanaz Arezoumandan, Alice Chen-Plotkin, David J. Irwin, Wiesje M. van der Flier, Afina W. Lemstra, Charlotte E. Teunissen

Related Publications

Explore these studies to deepen your understanding of the subject.

Medicine and Health

Automatic speech-based assessment to discriminate Parkinson's disease from essential tremor with a cross-language approach

C. D. Rios-urrego, J. Rusz, et al.

Medicine and Health

Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021

G. 2. D. Collaborators, D. Kanyin, et al.

Medicine and Health

A critical role of brain network architecture in a continuum model of autism spectrum disorders spanning from healthy individuals with genetic liability to individuals with ASD

B. Khundrakpam, N. Bhutani, et al.

Medicine and Health

The cryo-EM structure of the bd oxidase from *M. tuberculosis* reveals a unique structural framework and enables rational drug design to combat TB

S. Safarian, H. K. Opel-reading, et al.

Listen, Learn & Level Up

Over 10,000 hours of research content in 25+ fields, available in 12+ languages.

No more digging through PDFs, just hit play and absorb the world's latest research in your language, on your time.

listen to research audio papers with researchbunny