CRISPR/Cas9: implication for modeling and therapy of amyotrophic | ResearchBunny

Index

Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease lacking effective treatments. Recent advancements in ALS genomics have linked genes to phenotypes, prompting the development of new therapeutic strategies and improved animal models. This review examines the history of gene editing tools, current ALS models, and the application of CRISPR/Cas9 in ALS research and therapy.

Publisher

Frontiers in Neuroscience

Published On

Jan 01, 2024

Authors

Yajun Shi, Yan Zhao, Likui Lu, Qinqin Gao, Dongyi Yu, Miao Sun

Related Publications

Explore these studies to deepen your understanding of the subject.

Chemistry

Application of chemometrics for modeling and optimization of ultrasound-assisted dispersive liquid–liquid microextraction for the simultaneous determination of dyes

S. Shojaei, S. Shojaei, et al.

Engineering and Technology

Nanoparticles and convergence of artificial intelligence for targeted drug delivery for cancer therapy: Current progress and challenges

R. P. Singh, A. Natarajan, et al.

$Combination of pre-adapted bacteriophage therapy and antibiotics for treatment of fracture-related infection due to pandrug-resistant *Klebsiella pneumoniae*$

Medicine and Health

Combination of pre-adapted bacteriophage therapy and antibiotics for treatment of fracture-related infection due to pandrug-resistant *Klebsiella pneumoniae*

A. Eskenazi, C. Lood, et al.

Medicine and Health

Targeting USP2 regulation of VPRBP-mediated degradation of p53 and PD-L1 for cancer therapy

J. Yi, O. Tavana, et al.

Listen, Learn & Level Up

Over 10,000 hours of research content in 25+ fields, available in 12+ languages.

No more digging through PDFs—just hit play and absorb the world's latest research in your language, on your time.

listen to research audio papers with researchbunny