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Consistent survival in consecutive cases of life-supporting porcine kidney xenotransplantation using 10GE source pigs

Medicine and Health

Consistent survival in consecutive cases of life-supporting porcine kidney xenotransplantation using 10GE source pigs

D. Eisenson, Y. Hisadome, et al.

Explore the groundbreaking study on pig-to-nonhuman primate kidney xenotransplantation, revealing consistent long-term survival outcomes that pave the way for clinical advancements in addressing the organ shortage crisis. This compelling research was conducted by a team of experts.

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Playback language: English
Abstract
Xenotransplantation offers a potential solution to the organ shortage crisis. This study presents consistent survival in consecutive cases of pig-to-nonhuman primate (NHP) kidney xenotransplantation, achieving long-term survival even after significant cold preservation time and using FDA-approved immunosuppression. This provides critical evidence for the safety and feasibility of clinical kidney xenotransplantation, and suggests that long-term survival without CD40/CD154 costimulatory blockade is possible.
Publisher
Nature Communications
Published On
Apr 18, 2024
Authors
Daniel Eisenson, Yu Hisadome, Michelle Santillan, Hayato Iwase, WeiLi Chen, Akira Shimizu, Alex Schulick, Du Gu, Armaan Akbar, Alice Zhou, Kristy Koenig, Kasinath Kuravi, Farzana Rahman, Lori Sorrells, Lars Burdorf, Kristina DeSmet, Daniel Warren, Leigh Peterson, Marc Lorber, David Ayares, Andrew Cameron, Kazuhiko Yamada
Tags
Xenotransplantation
Kidney Transplant
Organ Shortage
Immunosuppression
Long-term Survival

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