Medicine and Health

Combining machine learning and nanopore construction creates an artificial intelligence nanopore for coronavirus detection

M. Taniguchi, S. Minami, et al.

This groundbreaking research by Masateru Taniguchi and colleagues introduces a cutting-edge method for rapid detection of coronaviruses using nanopores and AI, achieving remarkable sensitivity and specificity in just 5 minutes—all without RNA extraction.

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Abstract

High-throughput, high-accuracy detection of emerging viruses is crucial for controlling outbreaks. This paper presents a novel method for detecting coronaviruses using nanopores and artificial intelligence, eliminating the need for RNA extraction. The platform, termed the artificially intelligent nanopore, accurately identified four coronaviruses (HCoV-229E, SARS-CoV, MERS-CoV, and SARS-CoV-2) in saliva samples with 90% sensitivity and 96% specificity within 5 minutes.

Publisher

Nature Communications

Published On

Jun 17, 2021

Authors

Masateru Taniguchi, Shohei Minami, Chikako Ono, Rina Hamajima, Ayumi Morimura, Shigeto Hamaguchi, Yukihiro Akeda, Yuta Kanai, Takeshi Kobayashi, Wataru Kamitani, Yutaka Terada, Koichiro Suzuki, Nobuaki Hatori, Yoshiaki Yamagishi, Nobuei Washizu, Hiroyasu Takei, Osamu Sakamoto, Norihiko Naono, Kenji Tatematsu, Takashi Washio, Yoshiharu Matsuura, Kazunori Tomono

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