Medicine and Health

Chronic ultraviolet irradiation induces memory deficits via dysregulation of the dopamine pathway

K. Yoon, S. Y. Kim, et al.

This groundbreaking research by Kyeong-No Yoon and colleagues reveals the alarming effects of chronic UV radiation on neurobehavioral functions in a mouse model, highlighting memory deficits and changes in dopamine levels. Discover how these findings could reshape our understanding of UV exposure's impact on the brain and behavior.

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Playback language: English

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Abstract

This study investigated the mechanisms underlying UV radiation-induced neurobehavioral changes in a mouse model. UV irradiation induced hippocampal memory deficits, impaired synaptic plasticity, reduced adult neurogenesis, and increased dopamine levels in the skin, adrenal glands, and brain. Chronic UV exposure altered genes involved in dopaminergic neuron differentiation. A dopamine D1/D5 receptor antagonist reversed these changes. The findings suggest that chronic UV exposure alters dopamine levels, contributing to neurobehavioral shifts.

Publisher

Experimental & Molecular Medicine

Published On

Jun 03, 2024

Authors

Kyeong-No Yoon, Sun Yong Kim, Jungeun Ji, Yidan Cui, Qing-Ling Quan, Gunhyuk Park, Jang-Hee Oh, Ji Su Lee, Joon-Yong An, Jin Ho Chung, Yong-Seok Lee, Dong Hun Lee

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