Medicine and Health

Characterization of a pluripotent stem cell-derived matrix with powerful osteoregenerative capabilities

E. P. Mcneill, S. Zeitouni, et al.

Discover groundbreaking research by Eoin P. McNeill and colleagues on a revolutionary stem cell line derived from induced pluripotent stem cells that could transform bone fracture treatments. This new osteogenic cell-matrix outshines traditional healing methods, potentially providing a better alternative to autografts and BMP products in bone tissue engineering.

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Abstract

Current bone fracture treatments have limitations in effectiveness, cost, and side effects. This research presents a highly osteogenic mesenchymal stem cell (MSC) line derived from induced pluripotent stem cells (iPSCs). These cells produce a large quantity of osteogenic cell-matrix (ihOCM) in vitro. In mice, ihOCM surpasses bone morphogenetic protein 2 (BMP2) in healing calvarial defects within four weeks, a process partly mediated by collagen VI and XII. ihOCM shows promise as a replacement for autografts and BMP products in bone tissue engineering.

Publisher

Nature Communications

Published On

Jun 15, 2020

Authors

Eoin P. McNeill, Suzanne Zeitouni, Simin Pan, Andrew Haskell, Michael Cesarek, Daniel Tahan, Bret H. Clough, Ulf Krause, Lauren K. Dobson, Mayra Garcia, Christopher Kung, Qingguo Zhao, W. Brian Saunders, Fei Liu, Roland Kaunas, Carl A. Gregory

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