BiologyNot specified in the provided text

Characterization of a novel HLA-C allele, HLA-C*05:278N

M. Devriese, S. D. Silva, et al.

Discover the groundbreaking identification of a novel HLA-C allele, HLA-C*05:278N, linked to renal transplantation. This study by Magali Devriese, Sephora Da Silva, Maryvonnick Carmagnat, and Jean-Luc Taupin reveals the genetic intricacies like a nucleotide mismatch leading to a null allele with no cell surface expression. Dive into the specifics and implications of this exciting research.... show more

General Summary Metrics

Abstract

Compared with HLA-C*05:01:01:02, the novel allele HLA-C*05:278N carries a single nucleotide substitution (G>A) at position 1767 in exon 4, converting codon 244 from TGG (tryptophan) to TGA (stop). The resulting premature stop codon is predicted to render the allele null with no cell-surface expression. Serological typing by micro-lymphocyte cytotoxicity could not be performed due to lack of HLA-C reagents.

Publisher

Not specified in the provided text

Published On

Jan 01, 2023

Authors

Magali Devriese, Sephora Da Silva, Maryvonnick Carmagnat, Jean-Luc Taupin

Explore these studies to deepen your understanding

Adjacent work that informs or extends this paper's methodology and findings.

Agriculture

Characterization of phyllosphere endophytic lactic acid bacteria reveals a potential novel route to enhance silage fermentation quality

H. Zhou, S. Jia, et al.

Space Sciences

Stellar Characterization and a Chromospheric Activity Analysis of a K2 Sample of Planet-Hosting Stars

V. Loaiza-tacuri, K. Cunha, et al.

Medicine and Health

A Multicenter Randomized Controlled Trial of Microbiome-Based Artificial Intelligence-Assisted Personalized Diet vs Low-Fermentable Oligosaccharides, Disaccharides, Monosaccharides, and Polyols Diet: A Novel Approach for the Management of Irritable Bowel Syndrome

V. Tunali, N. Ç. Arslan, et al.

Psychology

Characterization of neural networks involved in transdiagnostic emotion dysregulation from a pilot randomized controlled trial of a neurostimulation-enhanced behavioral intervention

A. D. Neacsiu, N. Gerlus, et al.

Listen, Learn & Level Up

Over 10,000 hours of research content in 25+ fields, available in 22+ languages.

No more digging through PDFs, just hit play and absorb the world's latest research in your language, on your time.

listen to research audio papers with researchbunny