Compound heat anomalies, such as hot-dry and hot-wet events, pose significant health risks. This study uses ambulance dispatch data, air temperature, and relative humidity to investigate human impacts on these events in China. It finds that anthropogenic activities have increased hot-dry events by 2.34 times and decreased hot-wet events by 0.63 times over the past 40 years, particularly in the Yangtze River region. Under a carbon-neutral scenario by 2060, the study projects a reduction in high health-risk hot-dry and hot-wet events.