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Canine tumor mutational burden is correlated with TP53 mutation across tumor types and breeds

Veterinary Science

Canine tumor mutational burden is correlated with TP53 mutation across tumor types and breeds

B. A. Alsaihati, K. Ho, et al.

Explore the groundbreaking findings of a comprehensive study on canine tumors conducted by Burair A. Alsaihati and colleagues, revealing how tumor type influences mutation landscapes while breed independence prevails. This research uncovers vital pathways and the role of TP53 mutations.

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Playback language: English
Abstract
This study reanalyzes whole exome and genome sequencing data of 684 canine tumors across >7 common tumor types and >35 breeds. The results show that canine tumor alteration landscapes are tumor type-dependent but largely breed-independent. Each tumor type shows major pathway alterations similar to human counterparts. Tumor mutational burden (TMB) is associated with TP53 mutation but not PIK3CA mutation across tumor types and breeds. Golden Retrievers show a TMB-associated and osteosarcoma-enriched mutation signature. The study provides a comprehensive overview of canine mutations across major tumor types and breeds.
Publisher
Nature Communications
Published On
Aug 03, 2021
Authors
Burair A. Alsaihati, Kun-Lin Ho, Joshua Watson, Yuan Feng, Tianfang Wang, Kevin K. Dobbin, Shaying Zhao
Tags
canine tumors
genome sequencing
tumor mutational burden
TP53 mutation
osteosarcoma
pathway alterations
breeds
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