Psychology

Brain structural network alterations related to serum cortisol levels in drug-naïve, first-episode major depressive disorder patients: a source-based morphometric study

L. Nguyen, S. Kakeda, et al.

Discover groundbreaking insights into how gray matter networks are affected in drug-naïve major depressive disorder (MDD) patients and their surprising link to serum cortisol levels. This compelling study conducted by LeHoa Nguyen and colleagues reveals significant findings that could change the way we understand MDD's neurobiological underpinnings.

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Playback language: English

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Abstract

This study investigated the alterations in gray matter (GM) networks and their relationship with serum cortisol levels in first-episode, drug-naïve major depressive disorder (MDD) patients using source-based morphometry (SBM). Forty-two MDD patients and 39 controls were studied. MDD patients showed significantly higher serum cortisol levels. SBM analysis revealed two significantly different GM sources between groups: a prefrontal network and an insula-temporal network. Serum cortisol levels negatively correlated with the loading coefficients of the prefrontal network. Increased serum cortisol levels were associated with reductions in the prefrontal network in early-stage MDD, suggesting SBM as a useful approach for analyzing structural MRI data.

Publisher

Scientific Reports

Published On

Dec 16, 2020

Authors

LeHoa Nguyen, Shingo Kakeda, Keita Watanabe, Asuka Katsuki, Koichiro Sugimoto, Natsuki Igata, Takahiro Shinkai, Osamu Abe, Yukunori Korogi, Atsuko Ikenouchi, Reiji Yoshimura

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