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Abstract
Variation in cognitive trajectory during aging is only partially explained by common neurodegenerative pathologies. This study aimed to identify new molecular processes underlying this variation using brain microRNA profiles, integrated with brain transcriptome and proteome data. Analysis of four longitudinal cohorts identified miR-132-3p and miR-29a-3p as significant contributors to cognitive trajectory, independent of eight measured neurodegenerative pathologies. Integrative analyses revealed downstream targets of these microRNAs, suggesting their roles in cognitive stability.
Publisher
Translational Psychiatry
Published On
Feb 01, 2022
Authors
Aliza P. Wingo, Mengli Wang, Jiaqi Liu, Michael S. Breen, Hyun-Sik Yang, Beisha Tang, Julie A. Schneider, Nicholas T. Seyfried, James J. Lah, Allan I. Levey, David A. Bennett, Peng Jin, Philip L. De Jager, Thomas S. Wingo
Tags
cognitive trajectory
aging
microRNA
neurodegenerative pathologies
cognitive stability
brain transcriptome
molecular processes

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