Invasive electrical stimulation (IES) is prone to cause neural stimulus-inertia due to excessive accumulation of exogenous charges, leading to side effects and nerve regeneration failure. This study presents a wearable neural IES system for bionic and long-lasting neural modulation, automatically generating biomimetic pulsed electrical signals driven by respiratory motion. These signals provide biofeedback to respiratory behaviors, self-adjusting to different physiological states and modulating voltage-gated calcium channels. Cellular and animal experiments confirm effective elimination of neural stimulus-inertia, achieving unprecedented nerve regeneration and motor functional reconstruction in long-segmental peripheral nerve defects, comparable to autograft. This system offers an advanced platform to overcome neural stimulus-inertia and provides avenues for personalized IES therapy.
