This study utilized a bioengineered intestinal tubule to evaluate the intestinal efficacy of extracts from five *Lactuca* species, including domesticated *L. sativa* and wild relatives *L. serriola*, *L. saligna*, and *L. virosa*. The researchers assessed epithelial barrier integrity, cell viability, cell attachment, brush border enzyme activity, and immune markers. *L. sativa* cv. Salinas extracts decreased cell attachment and brush border enzyme activity, while extracts from *L. saligna* and *L. virosa* negatively impacted several parameters. The bioengineered tubule offers a potential tool for evaluating the safety and nutritional properties of lettuce breeding materials.
Publisher
npj Science of Food
Published On
Dec 13, 2022
Authors
Paulus G. M. Jochems, Bo Heming, Dmitry Lapin, Naomi E. L. Moonen, Guido Van den Ackerveken, Rosalinde Masereeuw
Tags
Lactuca
intestinal efficacy
bioengineered tubule
cell viability
brush border enzyme activity
nutritional properties
epithelial barrier
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