logo
ResearchBunny Logo
Abstract
This multicenter, open-label, randomized phase 2/3 study assessed the safety and immunogenicity of GEMCOVAC-OM, an Omicron-specific self-amplifying mRNA vaccine, as a booster in adults previously vaccinated with BBV152 or ChAdOx1 nCoV-19. GEMCOVAC-OM was well-tolerated. Phase 2 compared GEMCOVAC-OM to GEMCOVAC-19 (D614G variant-specific), showing higher IgG titers and seroconversion with GEMCOVAC-OM. Phase 3 compared GEMCOVAC-OM to ChAdOx1 nCoV-19, demonstrating GEMCOVAC-OM's superiority in neutralizing antibody titers and seroconversion rates. GEMCOVAC-OM proved safe and boosted immunity against the B.1.1.529 variant.
Publisher
Nature Medicine
Published On
May 01, 2024
Authors
Amit Saraf, Rohan Gurjar, Swarnendu Kaviraj, Aishwarya Kulkarni, Durgesh Kumar, Ruta Kulkarni, Rashmi Virkar, Jayashri Krishnan, Anjali Yadav, Ekta Baranwal, Ajay Singh, Arjun Raghuwanshi, Praveen Agarwal, Laxman Savergave, Sanjay Singh, Himanshu Pophale, Prakash Shende, Ravindra Baban Shinde, Vikram Vikhe, Abhishek Karmalkar, Bhaskar Deshmukh, Krishna Giri, Shrikant Deshpande, Ajay Bulle, Md. Sabah Siddiqui, Swapnav Borthakur, V. Reddy Tummuru, A. Venkateshwar Rao, Dhaiwat Shukla, Manish Kumar Jain, Pankaj Bhardwaj, Pravin Dinkar Supe, Manoja Kumar Das, Manoj Lahoti, Vijayakumar Barge
Tags
GEMCOVAC-OM
mRNA vaccine
Omicron variant
immunogenicity
safety
neutralizing antibodies
boosting immunity

Related Publications

Explore these studies to deepen your understanding of the subject.

A first-in-class leucyl-tRNA synthetase inhibitor, ganfeborole, for rifampicin-susceptible tuberculosis: a phase 2a open-label, randomized trial
Medicine and Health

A first-in-class leucyl-tRNA synthetase inhibitor, ganfeborole, for rifampicin-susceptible tuberculosis: a phase 2a open-label, randomized trial

A. H. Diacon, C. E. B. Iii, et al.

Multiple vaccine comparison in the same adults reveals vaccine-specific and age-related humoral response patterns: an open phase IV trial
Medicine and Health

Multiple vaccine comparison in the same adults reveals vaccine-specific and age-related humoral response patterns: an open phase IV trial

M. V. D. Heiden, S. Shetty, et al.

Artificial intelligence guided screening for cardiomyopathies in an obstetric population: a pragmatic randomized clinical trial
Medicine and Health

Artificial intelligence guided screening for cardiomyopathies in an obstetric population: a pragmatic randomized clinical trial

D. A. Adedinsewo, A. C. Morales-lara, et al.

Effectiveness of mRNA COVID-19 vaccine booster doses against Omicron severe outcomes
Medicine and Health

Effectiveness of mRNA COVID-19 vaccine booster doses against Omicron severe outcomes

R. Grewal, L. Nguyen, et al.

Listen, Learn & Level Up
Over 10,000 hours of research content in 25+ fields, available in 12+ languages.
No more digging through PDFs—just hit play and absorb the world's latest research in your language, on your time.
listen to research audio papers with researchbunny