Biology

An archaeal lid-containing feruloyl esterase degrades polyethylene terephthalate

P. Perez-garcia, J. Chow, et al.

Discover PET46, an innovative archaeal feruloyl esterase capable of degrading PET, comparable in activity to known bacterial PETases. This exciting research, conducted by a team from the University of Hamburg and Heinrich Heine University Düsseldorf, unveils a unique crystal structure that expands our understanding of PET-hydrolyzing enzymes.

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Index

Abstract

This paper reports the discovery and characterization of PET46, an archaeal feruloyl esterase with PET-degrading activity. PET46, originating from a deep-sea Candidatus Bathyarchaeota archaeon, exhibits comparable activity to known bacterial PETases on semi-crystalline PET and higher activity on BHET and MHET. Its crystal structure reveals a unique lid domain involved in substrate binding, expanding the diversity of known PET-hydrolyzing enzymes.

Publisher

COMMUNICATIONS CHEMISTRY

Published On

May 11, 2023

Authors

Pablo Perez-Garcia, Jennifer Chow, Elisa Costanzi, Marno Gurschke, Jonas Dittrich, Robert F. Dierkes, Rebecka Molitor, Violetta Applegatte, Golo Feuerriegel, Prince Tete, Dominik Danso, Stephan Thies, Julia Schumacher, Christopher Pfleger, Karl-Erich Jaeger, Holger Gohlke, Sander H. J. Smits, Ruth A. Schmitz, Wolfgang R. Streit

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