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Abstract
This study investigated the gut microbiota composition in Wilson's disease (WD) patients compared to healthy controls using 16S rRNA sequencing. WD patients exhibited significantly lower gut microbiota diversity and altered composition, with increased abundance of *Gemellaceae*, *Pseudomonadaceae*, and *Spirochaetaceae* and decreased abundance of Actinobacteria, Firmicutes, and Verrucomicrobia. Functional analysis revealed lower abundance of pathways related to host immune and metabolism. These findings suggest gut microbiota dysbiosis may contribute to WD pathogenesis.
Publisher
Scientific Reports
Published On
Dec 11, 2020
Authors
Xiangsheng Cai, Lin Deng, Xiaogui Ma, Yusheng Guo, Zhiting Feng, Minqi Liu, Yubin Guan, Yanting Huang, Jianxin Deng, Hongwei Li, Hong Sang, Fang Liu, Xiaorong Yang
Tags
Wilson's disease
gut microbiota
16S rRNA sequencing
dysbiosis
microbial diversity
pathogenesis

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