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Abstract
Ionizable lipid nanoparticles (LNPs) are crucial for mRNA delivery. This study presents the AGILE platform, combining deep learning and combinatorial chemistry to accelerate LNP development. AGILE designs, synthesizes, and evaluates lipids, revealing cell-specific preferences and highlighting its potential for creating customized LNPs for broader mRNA therapy applications.
Publisher
Nature Communications
Published On
Jul 26, 2024
Authors
Yue Xu, Shihao Ma, Haotian Cui, Jingan Chen, Shufen Xu, Fanglin Gong, Alex Golubovic, Muye Zhou, Kevin Chang Wang, Andrew Varley, Rick Xing Ze Lu, Bo Wang, Bowen Li
Tags
Ionizable lipid nanoparticles
mRNA delivery
AGILE platform
deep learning
combinatorial chemistry
lipid development
customized therapies

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