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Aerosol capture and coronavirus spike protein deactivation by enzyme functionalized antiviral membranes

Engineering and Technology

Aerosol capture and coronavirus spike protein deactivation by enzyme functionalized antiviral membranes

R. Mills, R. J. Vogler, et al.

This groundbreaking research by Rollie Mills and colleagues introduces nanostructured membranes that effectively filter coronavirus-sized aerosols while also denaturing the virus's spike glycoproteins using a multifunctional approach. With impressive filtration efficiencies exceeding 98.90% for tiny particles, this technology represents a significant advancement in virus protection in low-hydration environments.

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Playback language: English
Abstract
This paper reports on nanostructured membranes with tunable thickness and porosity for filtering coronavirus-sized aerosols, combined with antiviral enzyme functionalization that can denature spike glycoproteins of the SARS-CoV-2 virus in low-hydration environments. Thin, asymmetric membranes with subtilisin enzyme and methacrylic functionalization show >98.90% filtration efficiency for 100-nm particles. Unfunctionalized membranes provided a protection factor of 540±380 for coronavirus-sized particles. SARS-CoV-2 spike glycoprotein was denatured in 30s by subtilisin enzyme-functionalized membranes with 0.02-0.2% water content.
Publisher
Communications Materials
Published On
May 24, 2022
Authors
Rollie Mills, Ronald J. Vogler, Matthew Bernard, Jacob Concolino, Louis B. Hersh, Yinan Wei, Jeffrey Todd Hastings, Thomas Dziubla, Kevin C. Baldridge, Dibakar Bhattacharyya
Tags
nanostructured membranes
filtration efficiency
SARS-CoV-2
antiviral enzyme
spike glycoprotein
coronavirus-sized aerosols
functionalization

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