Medicine and Health

A molecular architectural design that promises potent antimicrobial activity against multidrug-resistant pathogens

B. Yuan, J. Liu, et al.

This innovative research by Bing Yuan, Jiaojiao Liu, Zhixiang Deng, and others unveils a groundbreaking class of synthetic antibacterial complexes that significantly enhance antimicrobial efficiency, proving effective against multidrug-resistant pathogens while minimizing cytotoxicity. Discover how PEG12k-1*Me could change the landscape of antibacterial treatment.

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Abstract

This research introduces a novel class of synthetic antibacterial complexes designed using melittin (Mel) and poly(ethylene glycol) (PEG) as building blocks. The flexibly linear complex PEG12k-1*Me demonstrated significantly enhanced antimicrobial efficiency (up to 500% improvement over Mel), excellent in vitro activity against multidrug-resistant pathogens (MICs of 2–32 µg mL⁻¹), and reduced in vivo cytotoxicity and acute toxicity. The mechanism involves lipid-specific membrane recognition and accelerated membrane perforation.

Publisher

NPG Asia Materials

Published On

Nov 16, 2021

Authors

Bing Yuan, Jiaojiao Liu, Zhixiang Deng, Lin Wei, Wenwen Li, Yujiang Dou, Zhonglan Chen, Che Zhang, Yu Xia, Jing Wang, Mengling Zhang, Kai Yang, Yuqiang Ma, Zhenhui Kang

DOI

https://doi.org/10.1038/s41427-021-00287-y

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