Biology

A de novo matrix for macroscopic living materials from bacteria

S. Molinari, R. F. T. Jr., et al.

This exciting research by Sara Molinari and colleagues unveils the development of engineered living materials (ELMs) using *Caulobacter crescentus* cells. By creatively manipulating a self-interacting protein, they formed centimeter-scale ELMs, revealing new design rules to enhance their properties and functions.

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Abstract

This paper reports the growth of engineered living materials (ELMs) from *Caulobacter crescentus* cells displaying and secreting a self-interacting protein. This protein formed a de novo matrix, assembling cells into centimeter-scale ELMs. The authors discovered design and assembly rules allowing them to tune the ELMs' composition, mechanical properties, and functionality, providing a foundation for robustly engineering ELMs with desirable macroscopic functions.

Publisher

Nature Communications

Published On

Sep 21, 2022

Authors

Sara Molinari, Robert F. Tesoriero Jr., Dong Li, Swetha Sridhar, Rong Cai, Jayasree Soman, Kathleen R. Ryan, Paul D. Ashby, Caroline M. Ajo-Franklin

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