Veterinary Science

A chimeric vaccine protects farmed saltwater crocodiles from West Nile virus-induced skin lesions

G. Habarugira, J. J. Harrison, et al.

Discover how a chimeric virus vaccine combining Binjari and West Nile virus genes has shown promise in preventing skin lesions in farmed crocodiles, with promising results from research conducted by Gervais Habarugira and collaborators.

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Abstract

West Nile virus (WNV) causes skin lesions in farmed crocodiles, resulting in economic losses. This study tested chimeric virus vaccines combining Binjari virus (BinJV) non-structural genes and WNV structural protein genes. The BinJV/WNV chimera elicited a robust neutralizing antibody response in saltwater crocodiles and protected against viremia and skin lesions after WNV challenge. This suggests the BinJV/WNV chimera is a safe and effective vaccine for preventing WNV-induced skin lesions in farmed crocodilians.

Publisher

npj Vaccines

Published On

Jun 27, 2023

Authors

Gervais Habarugira, Jessica J. Harrison, Jasmin Moran, Willy W. Suen, Agathe M. G. Colmant, Jody Hobson-Peters, Sally R. Isberg, Helle Bielefeldt-Ohmann, Roy A. Hall

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