Engineering and Technology

4D printing of stretchable nanocookie@conduit material hosting biocues and magnetoelectric stimulation for neurite sprouting

J. Fang, H. Hsu, et al.

This groundbreaking research by Jen-Hung Fang and colleagues reveals how electromagnetized carbon porous nanocookies (NCs) can enhance neuron cell differentiation and proliferation, paving the way for innovative therapies in nerve regeneration. By employing 4D printing, this study showcases how NCs facilitate growth factor release under electromagnetic stimulation, promising significant advancements in neural engineering.

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Abstract

This study demonstrates that electromagnetized carbon porous nanocookies (NCs) facilitate magnetoelectric conversion for growth factor release and cell stimulation, promoting neuron cell differentiation and proliferation in vitro and in vivo. Using 4D printing, NCs are surface-exposed, enhancing cell adhesion and enabling direct electromagnetic stimulation. Growth factors encapsulated in NC@conduit show excellent permeability and on-demand release, improving myelin sheath formation and axon orientation in vivo. This research provides a proof-of-concept for MF-guided in vivo neuron regeneration.

Publisher

NPG Asia Materials

Published On

Jan 30, 2020

Authors

Jen-Hung Fang, Hao-Hsiang Hsu, Ru-Siou Hsu, Chih-Kang Peng, Yu-Jen Lu, You-Yin Chen, San-Yuan Chen, Shang-Hsiu Hu

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